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A systematic review and meta-analysis conducted by In summary, some controversies remain regarding the effects of SSRIs on embryonic development, and heterogeneity may exist owing to the different definitions of congenital malformations used in different studies, especially those related to CHD (Figure 2)

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8 Direct action on the skin is a possible mechanism, as GLP-1Rs have been shown to be expressed in the skin of newborn mice and cultured skin cells